zepbound 12.5mg

1. Role of the $12.5\text{ mg}$ Dose

The $12.5\text{ mg}$ dose is one of the available strengths of Zepbound and is typically used as a maintenance dose after a patient has gradually escalated from lower doses.

• Dose Escalation: Zepbound treatment typically begins with a $2.5\text{ mg}$ dose for four weeks, and the dose is increased every four weeks by $2.5\text{ mg}$ increments to minimize gastrointestinal side effects. The dosage progression would look like $2.5\text{ mg}$, then $5\text{ mg}$, then $7.5\text{ mg}$, then $10\text{ mg}$, and then potentially $12.5\text{ mg}$.
• Maintenance Dose: The recommended maintenance dosages for weight loss and long-term weight management are $5\text{ mg}$, $10\text{ mg}$, or $15\text{ mg}$ once weekly. For Obstructive Sleep Apnea (OSA), the recommended maintenance dose is $10\text{ mg}$ or $15\text{ mg}$ once weekly. The $12.5\text{ mg}$ dose is an intermediate step or can be a maintenance dose, depending on a patient’s individual response and tolerability.
• Administration: It is administered as a once-weekly subcutaneous injection using a pre-filled single-dose pen or single-dose vial.